There are different reasons behind the error “Nexus Mod Manager is not set up to work with Skyrim”. Sometimes, however, you may encounter various errors when using NMM, such as NMM a problem occurred during install, and NMM is not set up to work with Skyrim. It is an all-rounder interface that can manage game files easily.
The Nexus Mod Manager is practical software that can help you install and uninstall any game mods. Change the Directory of Nexus Mod Manager
